Integrative Analysis of Histopathological Images and Genomic Data in Colon Adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) is one of the most common malignant tumors in the world. The histopathological features are crucial for the diagnosis, prognosis, and therapy of COAD.

Methods

We downloaded 719 whole-slide histopathological images from TCIA, and 459 corresponding HTSeq-counts mRNA expression and clinical data were obtained from TCGA. Histopathological image features were extracted by CellProfiler. Prognostic image features were selected by the least absolute shrinkage and selection operator (LASSO) and support vector machine (SVM) algorithms. The co-expression gene module correlated with prognostic image features was identified by weighted gene co-expression network analysis (WGCNA). Random forest was employed to construct an integrative prognostic mode

SUBMITTER: Li H 

PROVIDER: S-EPMC8504715 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature