Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel syndrome.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is a multi-faceted gastrointestinal disorder where food intake often triggers symptoms. Metabolomics may provide mechanistical insights to why responses to dietary modifications are diverse.

Objective

This study aimed to identify metabolite patterns related to dietary intake in patients with IBS, and to identify metabolites driving the separation between responders and non-responders to treatment.

Methods

Participants were randomized to a low fermentable oligo-, di-, monosaccharide and polyol (FODMAP) diet (LFD) or traditional IBS diet (TID) for four weeks. Fasting serum and urine samples pre- and post-intervention were analyzed using 1H nuclear magnetic resonance (NMR) metabolomics. Response to treatment was defined as a redu

SUBMITTER: Nybacka S 

PROVIDER: S-EPMC8504738 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature