3D modelling of drug-coated balloons for the treatment of calcified superficial femoral arteries.

ABSTRACT:

Background/objectives

Drug-coated balloon therapy for diseased superficial femoral arteries remains controversial. Despite its clinical relevance, only a few computational studies based on simplistic two-dimensional models have been proposed to investigate this endovascular therapy to date. This work addresses the aforementioned limitation by analyzing the drug transport and kinetics occurring during drug-coated balloon deployment in a three-dimensional geometry.

Methods

An idealized three-dimensional model of a superficial femoral artery presenting with a calcific plaque and treated with a drug-coated balloon was created to perform transient mass transport simulations. To account for the transport of drug (i.e. paclitaxel) released by the device, a diffusion-reaction equati

SUBMITTER: Colombo M 

PROVIDER: S-EPMC8504744 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature