Alterations in children's sub-dominant gut microbiota by HIV infection and anti-retroviral therapy.

ABSTRACT:

Objective

We investigated the impact of human immunodeficiency virus (HIV) infection and anti-retroviral therapy (ART) on the gut microbiota of children.

Design

This cross-sectional study investigated the gut microbiota of children with and without HIV.

Methods

We collected fecal samples from 59 children with HIV (29 treated with ART [ART(+)] and 30 without ART [HIV(+)]) and 20 children without HIV [HIV(-)] in Vietnam. We performed quantitative RT-PCR to detect 14 representative intestinal bacteria targeting 16S/23S rRNA molecules. We also collected the blood samples for immunological analyses.

Results

In spearman's correlation analyses, no significant correlation between the number of dominant bacteria and age was found among children in the HIV(-) group. Howe

SUBMITTER: Nguyen QT 

PROVIDER: S-EPMC8504761 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature