Immune response profiling in patients with traumatic injuries associated with alcohol ingestion.

ABSTRACT: Traumatic injuries afflict more than 5 million people globally every year. Current and past animal research has demonstrated association among alcohol, trauma, and impaired immune function, whereas human registries have shown association between alcohol and morbidity as well as mortality. The purpose of this study is to elucidate the immune interactions with alcohol in traumatically injured patients. We prospectively enrolled 379 patients after trauma at three medical centers in the Surgical Critical Care Initiative. Plasma was analyzed using Luminex for up to 35 different cytokines. Collected samples were grouped by patients with detectable plasma alcohol levels versus those without. Univariate testing determined differences in analytes between groups. We built Bayesian belief networks wi

SUBMITTER: Breslin AW 

PROVIDER: S-EPMC8504819 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature