Effects of 5-HT_₃ receptor antagonists on cisplatin-induced kidney injury.

ABSTRACT: Nausea, vomiting, and renal injury are the common adverse effects associated with cisplatin. Cisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin-induced kidney injury has been reported. The MATE transporter is also involved in the excretion of ondansetron, but the effects of 5-HT₃ receptor antagonists used clinically for cisplatin-induced renal injury have not been elucidated. Therefore, the aim of this study was to investigate the effects of 5-HT₃ receptor antagonists in a mouse model of cisplatin-induced kidney injury and to validate the results using medical big data analysis of more than 1.4 million reports and a survey of 3000 hospital medical records. The concomitant use of a firs

SUBMITTER: Goda M 

PROVIDER: S-EPMC8504842 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature