Nonalcoholic fatty liver disease is a risk factor for glucose intolerance onset in men regardless of alanine aminotransferase status.

ABSTRACT:

Introduction

Fatty liver disease (FLD) is a surrogate condition for glucose intolerance development. FLD may involve normal or abnormal liver enzyme levels. Whether FLD is a risk factor for glucose intolerance, regardless of liver enzyme levels, remains unknown. We assessed relationships between the development of impaired fasting glucose (IFG) and FLD, liver enzyme abnormalities, and alcohol consumption.

Materials and methods

We retrospectively evaluated 8,664 participants with more than two annual health check-ups. Participants were classified according to sex, alcohol consumption, alanine aminotransferase (ALT) levels, and fatty liver status.

Results

In univariate analyses, IFG onset among men was related to normal or high ALT levels with FLD in the nonalcoholic an

SUBMITTER: Miyake T 

PROVIDER: S-EPMC8504916 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature