SARS-CoV-2 shedding dynamics across the respiratory tract, sex, and disease severity for adult and pediatric COVID-19.

ABSTRACT:

Background

Previously, we conducted a systematic review and analyzed the respiratory kinetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Chen et al., 2021). How age, sex, and coronavirus disease 2019 (COVID-19) severity interplay to influence the shedding dynamics of SARS-CoV-2, however, remains poorly understood.

Methods

We updated our systematic dataset, collected individual case characteristics, and conducted stratified analyses of SARS-CoV-2 shedding dynamics in the upper (URT) and lower respiratory tract (LRT) across COVID-19 severity, sex, and age groups (aged 0-17 years, 18-59 years, and 60 years or older).

Results

The systematic dataset included 1266 adults and 136 children with COVID-19. Our analyses indicated that high, persistent LRT s

SUBMITTER: Chen PZ 

PROVIDER: S-EPMC8504968 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature