Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts.

ABSTRACT: Treatment-resistant depression (TRD) is a major contributor to the disability caused by major depressive disorder (MDD). Primary care electronic health records provide an easily accessible approach to investigate TRD clinical and genetic characteristics. MDD defined from primary care records in UK Biobank (UKB) and EXCEED studies was compared with other measures of depression and tested for association with MDD polygenic risk score (PRS). Using prescribing records, TRD was defined from at least two switches between antidepressant drugs, each prescribed for at least 6 weeks. Clinical-demographic characteristics, SNP-based heritability (h²_SNP) and genetic overlap with psychiatric and non-psychiatric traits were compared in TRD and non-TRD MDD cases. In 230,096 and 8926

SUBMITTER: Fabbri C 

PROVIDER: S-EPMC8505242 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature