STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology.

ABSTRACT: The signal transducer and activator of transcription 3 (STAT3) signalling pathway is activated through phosphorylation by Janus kinases in response to a diverse set of immunogenic and non-immunogenic triggers. Several distinct lines of evidence propose an intricate involvement of STAT3 in neural function relevant to behaviour in health and disease. However, in part due to the pleiotropic effects resulting from its DNA binding activity and the consequent regulation of expression of a variety of genes with context-dependent cellular consequences, the precise nature of STAT3 involvement in the neural mechanisms underlying psychopathology remains incompletely understood. Here, we focused on the midbrain serotonergic system, a central hub for the regulation of emotions, to examine the relevance

SUBMITTER: Reisinger SN 

PROVIDER: S-EPMC8505245 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature