Structural MRI substrate of long-duration response to levodopa in Parkinson's disease: an exploratory study.

ABSTRACT:

Objective

The long-duration response (LDR) to L-dopa is a sustained benefit deriving from chronic administration of therapy to patients with Parkinson's disease (PD). Almost all patients with early PD may develop the LDR to L-dopa, even if some patients could not at given dosages of the drug. Aim of this exploratory study is to investigate whether a neuroanatomical substrate may underlie the development of the of LDR using structural magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) analysis.

Methods

Twenty-four drug-naïve PD patients were enrolled and underwent a baseline 3D T1-weighted structural brain MRI. Then, a treatment with 250/25 mg of L-dopa/carbidopa every 24 h was started and, after 2 weeks, LDR was evaluated by movement time recordings.

Resul

SUBMITTER: Donzuso G 

PROVIDER: S-EPMC8505285 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature