Respiratory parameters on diagnostic sleep studies predict survival in patients with amyotrophic lateral sclerosis.

ABSTRACT:

Objective

In amyotrophic lateral sclerosis (ALS), respiratory muscle involvement and sleep-disordered breathing relate to worse prognosis. The present study investigated whether respiratory outcomes on first-ever sleep studies predict survival in patients with ALS, specifically taking into account subsequent initiation of non-invasive ventilation (NIV).

Methods

From patients with ALS, baseline sleep study records, transcutaneous capnometry, early morning blood gas analysis, survival data and clinical disease characteristics were retrospectively analyzed. Patients were stratified according to whether enduring NIV was consecutively established ("NIV(+)") or not ("NIV(-)").

Results

Among the study cohort (n = 158, 72 female, 51 with bulbar onset ALS, 105 deceased) sleep-

SUBMITTER: Engel M 

PROVIDER: S-EPMC8505303 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature