A Pilot Double-Blind Placebo-Controlled Randomized Clinical Trial to Investigate the Effects of Early Enteral Nutrients in Sepsis.

ABSTRACT: Preclinical studies from our laboratory demonstrated therapeutic effects of enteral dextrose administration in the acute phase of sepsis, mediated by the intestine-derived incretin hormone glucose-dependent insulinotropic peptide. The current study investigated the effects of an early enteral dextrose infusion on systemic inflammation and glucose metabolism in critically ill septic patients.

Design

Single-center, double-blind, placebo-controlled randomized pilot clinical trial (NCT03454087).

Setting

Tertiary-care medical center in Pittsburgh, PA.

Patients

Critically ill adult patients within 48 hours of sepsis diagnosis and with established enteral access.

Interventions

Participants were randomized 1:1 to receive a continuous water (placebo) or enteral dextrose

SUBMITTER: Shah FA 

PROVIDER: S-EPMC8505333 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature