Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.

ABSTRACT: Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest. The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study.

Design

Prospective, single-arm study.

Setting

Tertiary care hospital.

Patients/subjects

Eight healthy adult participants.

Interventions

Subjects underwent hospitalized exposure to 2.4% hydrogen gas in medical air via high-flow nasal cannula (15 L/min) for 24 (n = 2), 48 (n = 2), or 72 (n = 4) hours.

Measurements and main results

Endpoints included vital signs, patient- and nurse-reported signs and symp

SUBMITTER: Cole AR 

PROVIDER: S-EPMC8505337 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature