Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/- mice.

ABSTRACT: Cocaine addiction causes serious health problems, and no effective treatment is available yet. We previously identified a genetic risk variant for cocaine addiction in the PLCB1 gene and found this gene upregulated in postmortem brains of cocaine abusers and in human dopaminergic neuron-like cells after an acute cocaine exposure. Here, we functionally tested the contribution of the PLCB1 gene to cocaine addictive properties using Plcb1+/- mice. First, we performed a general phenotypic characterization and found that Plcb1+/- mice showed normal behavior, although they had increased anxiety and impaired short-term memory. Subsequently, mice were trained for operant conditioning, self-administered cocaine for 10 days, and were tested for cocaine motivation. After extinction, we found a reduct

SUBMITTER: Cabana-Dominguez J 

PROVIDER: S-EPMC8505421 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature