Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults.

ABSTRACT: Cerebral beta amyloid (Aβ) deposition and late-life depression (LLD) are known to be associated with the trajectory of Alzheimer's disease (AD). However, their neurobiological link is not clear. Previous studies showed aberrant functional connectivity (FC) changes in the default mode network (DMN) in early Aβ deposition and LLD, but its mediating role has not been elucidated. This study was performed to investigate the distinctive association pattern of DMN FC linking LLD and Aβ retention in cognitively normal older adults. A total of 235 cognitively normal older adults with (n = 118) and without depression (n = 117) underwent resting-state functional magnetic resonance imaging and ¹⁸F-flutemetamol positron emission tomography to investigate the associations between Aβ burden, d

SUBMITTER: Wang SM 

PROVIDER: S-EPMC8505502 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature