Communication processes about predictive genetic testing within high-risk breast cancer families: a two-phase study design.

ABSTRACT: The detection of a pathogenic variant in the BRCA1 or BRCA2 gene has medical and psychological consequences for both, affected mutation carriers and their relatives. A two-phase study with explanatory sequential mixed methods design examined the psychological impact of genetic testing and associated family communication processes. Analyzing a survey data of 79 carriers of a BRCA1 or BRCA2 mutation, the majority had general psychological distress independent of cancer diagnosis in the patients' history. The point prevalence of depression was 16.9%. Contrary to their subjective perception, the respondents' knowledge about those mutations was moderate. Despite the high rate of information transfer to relatives at risk (100%), their reported uptake of genetic testing was low (45.6%). Communica

SUBMITTER: Blomen CL 

PROVIDER: S-EPMC8505562 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature