Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu₃) impairs postsynaptic plasticity and modulates affective behaviors.

ABSTRACT: Clinical and translational studies suggest that prefrontal cortex (PFC) dysregulation is a hallmark feature of several affective disorders. Thus, investigating the mechanisms involved in the regulation of PFC function and synaptic plasticity could aid in developing new medications. In recent years, the mGlu₂ and mGlu₃ subtypes of metabotropic glutamate (mGlu) receptors have emerged as exciting potential targets for the treatment of affective disorders, as mGlu_2/3 antagonists exert antidepressant-like effects across many rodent models. Several recent studies suggest that presynaptic mGlu₂ receptors may contribute to these effects by regulating excitatory transmission at synapses from the thalamus to the PFC. Interestingly, we found that mGlu₃

SUBMITTER: Joffe ME 

PROVIDER: S-EPMC8505649 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature