Role of the Mitochondrial Protein Import Machinery and Protein Processing in Heart Disease.

ABSTRACT: Mitochondria are essential organelles for cellular energy production, metabolic homeostasis, calcium homeostasis, cell proliferation, and apoptosis. About 99% of mammalian mitochondrial proteins are encoded by the nuclear genome, synthesized as precursors in the cytosol, and imported into mitochondria by mitochondrial protein import machinery. Mitochondrial protein import systems function not only as independent units for protein translocation, but also are deeply integrated into a functional network of mitochondrial bioenergetics, protein quality control, mitochondrial dynamics and morphology, and interaction with other organelles. Mitochondrial protein import deficiency is linked to various diseases, including cardiovascular disease. In this review, we describe an emerging class of prote

SUBMITTER: Zhao F 

PROVIDER: S-EPMC8505727 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature