Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans.

ABSTRACT: With over 220,000 cases and 180,000 deaths annually, Cryptococcus neoformans is the most common cause of fungal meningitis and a leading cause of death in HIV/AIDS patients in Sub-Saharan Africa. Either C. neoformans can be killed by innate airway phagocytes, or it can survive intracellularly. Pulmonary murine macrophage and dendritic cell (DC) subsets have been identified in the naïve lung, and we hypothesize that each subset has different interactions with C. neoformans. For these studies, we purified murine pulmonary macrophage and DC subsets from naïve mice - alveolar macrophages, Ly6c^- and Ly6c⁺ monocyte-like macrophages, interstitial macrophages, CD11b⁺ and CD103⁺ DCs. With each subset, we examined cryptococcal associat

SUBMITTER: Hawkins AN 

PROVIDER: S-EPMC8505728 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature