Interaction between insulin and androgen signalling in decidualization, cell migration and trophoblast invasion in vitro.

ABSTRACT: Finely tuned decidualization of endometrial stromal fibroblasts into decidual cells is crucial for successful implantation and a healthy pregnancy. Both insulin and androgens are known to modulate decidualization, however, their complex effect on this process has not been fully elucidated. As hyperinsulinemia and hyperandrogenism are associated in clinical conditions, we aimed to investigate the interaction between insulin and androgens on decidualization. Primary human endometrial stromal cells were decidualized in vitro in the presence of insulin and/or androgens (dihydrotestosterone (DHT), testosterone). Gene or protein expressions of decidualization markers were measured, and cells size characteristics were determined. Migration of decidualizing endometrial stromal cells and invasion o

SUBMITTER: Hirschberg AL 

PROVIDER: S-EPMC8505820 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature