The association between fat mass and obesity-associated (FTO) genotype and serum vitamin D level in breast cancer patients.

ABSTRACT: The preventive effect of vitamin D against breast cancer can be influenced by gene polymorphisms. This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross-sectional study was carried out on 180 newly diagnosed patients with breast cancer in Tehran, Iran. The blood samples were collected from the participants in order to assess the FTO gene rs9939609 polymorphism by the tetra-primer amplification refractory mutation system (Tetra-ARMS) PCR method. The serum level of 25(OH) vitamin D was measured using the direct competitive enzyme-linked immunosorbent assay (ELISA) method. The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders. The fr

SUBMITTER: Gholamalizadeh M 

PROVIDER: S-EPMC8505832 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature