Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells.

ABSTRACT: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Its high metastasis rate is significantly correlated with poor patient prognosis. Elucidating the molecular mechanism underlying HCC metastasis is essential for HCC treatment. Owing to their high conductance, large-conductance calcium-activated potassium channels (BK channels) play a critical role in the control of membrane potential and have repeatedly been proposed as potential targets for cancer therapy. Emerging evidence suggests that BK channels are involved in the progression of cancer malignancies. The present study investigated the role of BK channels in mediating the hypoxia-stimulated migration of HCC cells both in vitro and in vivo in the absence and presence of various BK channels modulators. W

SUBMITTER: He Y 

PROVIDER: S-EPMC8505838 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature