Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers.

ABSTRACT:

Background

Receptor tyrosine kinases (RTKs) are a class of tyrosine kinases that regulate cell-to-cell communication and control a variety of complex biological functions. Dysregulation of RTK signaling partly due to chromosomal rearrangements leads to novel tyrosine kinase fusion oncoproteins that are possibly driver alterations to cancers. Targeting some RTK fusions with specific tyrosine kinases inhibitors (TKIs) is an effective therapeutic strategy across a spectrum of RTK fusion-related cancers. However, there is still a paucity of extensive RTK fusion investigations in breast cancer. This study aims to characterize RTK fusions in Chinese breast cancer patients.

Methods

An in-house DNA sequencing database of 1440 Chinese breast cancer patients with a capture-based panel

SUBMITTER: Tao Z 

PROVIDER: S-EPMC8506003 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature