The potential mechanism of Astragali Radix in the treatment of children with nephrotic syndrome.

ABSTRACT:

Background

The molecular mechanism of Astragali Radix in the treatment of children with nephrotic syndrome (NS) is unclear. This study aimed to use network pharmacology to explore this potential mechanism.

Methods

The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to identify the main active ingredients of Astragali Radix. The PharmMapper, Online Mendelian Inheritance in Man (OMIM), and GeneCards databases were then used to identify the active ingredients of Astragali Radix. The String database and Cytoscape software were used to construct the protein-protein network. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using DAVID Database.

Results

In the TCMSP Data

SUBMITTER: Wen X 

PROVIDER: S-EPMC8506061 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature