Bioinformatics analysis reveals the roles of cytoskeleton protein transgelin in occurrence and development of proteinuria.

ABSTRACT:

Background

Proteinuria is a sensitive hallmark for progressive renal dysfunction. Transgelin (TAGLN) has been demonstrated to participate in etiology of proteinuria and dynamics of podocyte foot process; however, the mechanism of TAGLN involvement in proteinuria is unknown. The present study aimed to explore the roles of TAGLN in the development of proteinuria.

Methods

Differentially expressed genes (DEGs) were detected from microarray expression profiling datasets from Gene Expression Omnibus, and analyzed by the short time series expression miner to cluster the DEGs in proteinuria progression. Kyoto Encyclopedia of Genes and Genomes pathway analysis was used to determine the top 20 enriched pathways, and construct a gene interaction network.

Results

In total, 2,409

SUBMITTER: Ding Y 

PROVIDER: S-EPMC8506063 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature