Postnatal age is strongly correlated with the early development of the gut microbiome in preterm infants.

ABSTRACT:

Background

The gut microbiome plays a potential role in clinical events in preterm infants and may affect their lateral development. Understanding the initial colonization of microbes in the gut, their early dynamic changes, and the major factors correlated with these changes would provide crucial information about the developmental process in early life.

Methods

The present study enrolled 151 preterm infants and examined the longitudinal dynamics of their fecal microbiome profiles during the period of hospitalization using 16S ribosomal RNA gene sequencing. Random forest modeling was used to predict postnatal age (Age), postmenstrual age (PMA), and gestational age (GA), using gut microbiome features.

Results

Principal coordinate analysis revealed that the gut microbi

SUBMITTER: Shen W 

PROVIDER: S-EPMC8506066 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature