Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome.

ABSTRACT:

Importance

Younger age, oligoclonal bands, and infratentorial and spinal cord lesions are factors associated with an increased 10-year risk of clinical conversion from radiologically isolated syndrome (RIS) to multiple sclerosis (MS). Whether disease-modifying therapy is beneficial for individuals with RIS is currently unknown.

Objectives

To evaluate the 2-year risk of a clinical event (onset of clinical symptoms of MS) prospectively, identify factors associated with developing an early clinical event, and simulate the sample size needed for a phase III clinical trial of individuals with RIS meeting 2009 RIS criteria.

Design, setting, and participants

This cohort study used data on prospectively followed-up individuals with RIS identified at 1 of 26 tertiary centers f

SUBMITTER: Lebrun-Frenay C 

PROVIDER: S-EPMC8506228 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature