Association of Mitral Annular Disjunction With Cardiovascular Outcomes Among Patients With Marfan Syndrome.

ABSTRACT:

Importance

Mitral annular disjunction (MAD) has received particular interest in patients with mitral valve prolapse, ventricular tachycardia, and sudden cardiac death. The clinical significance of MAD for patients with Marfan syndrome (MFS) remains largely unexplored.

Objective

To define the prevalence of MAD and examine its association with cardiovascular outcomes and arrhythmia among patients with MFS.

Design, setting, and participants

This retrospective, single-center cohort study included 142 patients with a diagnosis of MFS based on the revised Ghent criteria and a confirmed (likely) pathogenic variant in the FBN1 gene who underwent regular follow-up between January 1, 2004, and December 31, 2019.

Main outcomes and measures

The presence of MAD was assessed

SUBMITTER: Demolder A 

PROVIDER: S-EPMC8506229 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature