Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis.

ABSTRACT:

Objective

To assess the effectiveness and safety of different preparations and doses of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and paracetamol for knee and hip osteoarthritis pain and physical function to enable effective and safe use of these drugs at their lowest possible dose.

Design

Systematic review and network meta-analysis of randomised trials.

Data sources

Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, regulatory agency websites, and ClinicalTrials.gov from inception to 28 June 2021.

Eligibility criteria for selecting studies

Randomised trials published in English with ≥100 patients per group that evaluated NSAIDs, opioids, or paracetamol (acetaminophen) to treat osteoarthritis.

Outcomes and measures

SUBMITTER: da Costa BR 

PROVIDER: S-EPMC8506236 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature