The Hidden Genomic Diversity, Specialized Metabolite Capacity, and Revised Taxonomy of <i>Burkholderia</i> Sensu Lato.

ABSTRACT: Burkholderia sensu lato is a collection of closely related genera within the family Burkholderiaceae that includes species of environmental, industrial, biotechnological, and clinical importance. Multiple species within the complex are the source of diverse specialized metabolites, many of which have been identified through genome mining of their biosynthetic gene clusters (BGCs). However, the full, true genomic diversity of these species and genera, and their biosynthetic capacity have not been investigated. This study sought to cluster and classify over 4000 Burkholderia sensu lato genome assemblies into distinct genomic taxa representing named and uncharacterized species. We delineated 235 species groups by average nucleotide identity analyses that formed seven distinct ph

SUBMITTER: Mullins AJ 

PROVIDER: S-EPMC8506256 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature