Neutrophil extracellular trap formation index predicts occurrences of deep surgical site infection after laparotomy.

ABSTRACT:

Background

Deep surgical site infections (DSSIs) are serious complications after laparotomy. Neutrophil extracellular traps (NETs) play a vital role in the development of DSSI. Here, we focused on a new approach to predicting the occurrence of DSSI through the detection of the NET formation index (NFI), and compared its prediction ability with other clinical infection indicators.

Methods

Patients who received laparotomy were prospectively enrolled in this study. General information, APACHE II score, SOFA score, and serum infection indicators were recorded. The postoperative abdominal drainage fluid was collected within 3 days after the operation for quantification of the NFI.

Results

A total of 92 consecutive patients were included, with 22 patients were diagnosed wit

SUBMITTER: Duan Z 

PROVIDER: S-EPMC8506538 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature