Cancer gene related characterization of patterns and point of recurrence after resection of colorectal liver metastases.

ABSTRACT:

Background

Outcome after resection of CRLM is hampered by a high rate of recurrence. There are little data about the role of cancer related genes and their mutations in this scenario. The aim of our analysis was to assess the predictive power of cancer-related genes and their mutations on risk for and distribution of recurrence and the time of occurrence after resection of colorectal liver metastases (CRLM).

Methods

We included 130 patients with 167 liver resections. The work-up consisted of the analysis of a total of 720 cancer-related genes by next-generation sequencing (NGS). Results were correlated with the patterns and time of recurrence and survival.

Results

At the time of analysis, 89/130 patients (68%) had developed recurrence. This included liver only recurre

SUBMITTER: Lang H 

PROVIDER: S-EPMC8506541 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature