Retraction to using a deep recurrent neural network with EEG signal to detect Parkinson's disease.
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ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC8506554 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Retraction to using a deep recurrent neural network with EEG signal to detect Parkinson's disease.
Xu Shixiao S Wang Zhihua Z Sun Jutao J Zhang Zhiqiang Z Wu Zhaoyun Z Yang Tiezhao T Xue Gang G Cheng Chuance C
Annals of translational medicine 20210901 17
[This retracts the article DOI: 10.21037/atm-20-5100.]. ...[more]
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Project description:BackgroundParkinson's disease (PD) is expected to become more common, particularly with an aging population. Diagnosis and monitoring of the disease typically rely on the laborious examination of physical symptoms by medical experts, which is necessarily limited and may not detect the prodromal stages of the disease.New methodWe propose a lightweight (~20 K parameters) deep learning model to classify resting-state EEG recorded from people with PD and healthy controls (HC). The proposed CRNN model consists of convolutional neural networks (CNN) and a recurrent neural network (RNN) with gated recurrent units (GRUs). The 1D CNN layers are designed to extract spatiotemporal features across EEG channels, which are subsequently supplied to the GRUs to discover temporal features pertinent to the classification.ResultsThe CRNN model achieved 99.2% accuracy, 98.9% precision, and 99.4% recall in classifying PD from HC. Interrogating the model, we further demonstrate that the model is sensitive to dopaminergic medication effects and predominantly uses phase information in the EEG signals.Comparison with existing methodsThe CRNN model achieves superior performance compared to baseline machine learning methods and other recently proposed deep learning model.ConclusionThe approach proposed in this study adequately extracts spatial and temporal features in multi-channel EEG signals that enable accurate differentiation between PD and HC. The CRNN model has excellent potential for use as an oscillatory biomarker for assisting in the diagnosis and monitoring of people with PD. Future studies to further improve and validate the model's performance in clinical practice are warranted.
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