LncRNA THRIL is involved in the proliferation, migration, and invasion of rheumatoid fibroblast-like synoviocytes.

ABSTRACT:

Background

Fibroblast-like synoviocytes (FLSs), which can migrate and directly invade the cartilage and the bone, are crucial players in joint damage in rheumatoid arthritis (RA). Nevertheless, the detailed mechanisms underlying the aberrant activation of RA FLSs remain unclear. Several studies have attempted to explore the relationship between long non-coding RNAs (lncRNAs) and RA pathology; however, the role of lncRNAs in RA is unknown. The present study aimed to determine the functions of tumor necrosis factor-α and heterogeneous nuclear ribonucleoprotein L-related immunoregulatory lincRNA (THRIL) in RA FLSs migration and invasion.

Methods

Small interfering RNA targeting THRIL or lentivirus overexpressing THRIL was used to knockdown or overexpress

SUBMITTER: Zou Y 

PROVIDER: S-EPMC8506560 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature