Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts.

ABSTRACT: Hydroxychloroquine (HCQ), clinically established in antimalarial and autoimmune therapy, recently raised cardiac arrhythmogenic concerns when used alone or with azithromycin (HCQ+AZM) in Covid-19. We report complementary, experimental, studies of its electrophysiological effects. In patch clamped HEK293 cells expressing human cardiac ion channels, HCQ inhibited I_Kr and I_K1 at a therapeutic concentrations (IC₅₀s: 10 ± 0.6 and 34 ± 5.0 μM). I_Na and I_CaL showed higher IC₅₀s; I_to and I_Ks were unaffected. AZM slightly inhibited I_Na, I_CaL, I_Ks, and I_Kr, sparing I_K1 and I_to. (HCQ+AZM) inhibited I_Kr and I_K1 (IC₅₀s

SUBMITTER: Wang G 

PROVIDER: S-EPMC8506600 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature