Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic ¹⁸F-Radiolabeling of Base-Sensitive Tracers.

ABSTRACT: Aliphatic nucleophilic substitution (S_N2) with [¹⁸F]fluoride is the most widely applied method to prepare ¹⁸F-labeled positron emission tomography (PET) tracers. Strong basic conditions commonly used during ¹⁸F-labeling procedures inherently limit or prohibit labeling of base-sensitive scaffolds. The high basicity stems from the tradition to trap [¹⁸F]fluoride on anion exchange cartridges and elute it afterward with basic anions. This sequence is used to facilitate the transfer of [¹⁸F]fluoride from an aqueous to an aprotic organic, polar reaction medium, which is beneficial for S_N2 reactions. Furthermore, this sequence also removes cationic radioactive contaminations from cyclotron-irradiated [¹⁸O]wate

SUBMITTER: Bratteby K 

PROVIDER: S-EPMC8506604 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature