The important roles and molecular mechanisms of annexin A₂ autoantibody in children with nephrotic syndrome.

ABSTRACT:

Background

In recent years, B-cell dysfunction has been found to play an important role in the pathogenesis of primary nephrotic syndrome (PNS). B cells play a pathogenic role by secreting antibodies against their target antigens after transforming into plasma cells. Therefore, this study aimed to screen the autoantibodies that cause PNS and explore their pathogenic mechanisms.

Methods

Western blotting and mass spectrometry were employed to screen and identify autoantibodies against podocytes in children with PNS. Both in vivo and in vitro experiments were used to study the pathogenic mechanism of PNS. The results were confirmed in a large multicenter clinical study in children.

Results

Annexin A₂ autoantibody was highly expressed in children

SUBMITTER: Ye Q 

PROVIDER: S-EPMC8506724 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature