The expression of heat shock protein A12B (HSPA12B) in non-Hodgkin's lymphomas.

ABSTRACT:

Background

Heat shock protein A12B (HSPA12B) plays a considerable protective role for cells, tissues, and organs against various noxious conditions. However, the expression of HSPA12B in cancer biology remains controversial. This study aimed to investigate the expression of HSPA12B and its role in cell adhesion mediated drug resistance (CAM-DR) of non-Hodgkin's lymphoma (NHL).

Methods

In this study, the expression of HSPA12B in NHL was determined by immunohistochemical, and the effect of HSPA12B expression on the prognosis of NHL was analyzed by Kaplan-Meier curves. Then, the transfection technique was used to research the effect of HSPA12B in cell apoptosis. The most important was to study the expression changes of HSPA12B in the adhesion model and the effect of overexpress

SUBMITTER: Huang Y 

PROVIDER: S-EPMC8506729 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature