A narrative review of non-coding RNAs in atrial fibrillation: potential therapeutic targets and molecular mechanisms.

ABSTRACT:

Objective

This review summarizes the advances in the study of ncRNAs and atrial remodeling mechanisms to explore potential therapeutic targets and strategies for AF.

Background

Atrial fibrillation (AF) is one of the most common arrhythmias, and its morbidity and mortality rates are gradually increasing. Non-coding ribonucleic acid RNAs (ncRNAs) are transcribed from the genome and do not have the ability to be translated into proteins. A growing body of evidence has shown ncRNAs are extensively involved in the pathophysiological processes underlying AF. However, the precise molecular mechanisms of these associations have not been fully elucidated. Atrial remodeling plays a key role in the occurrence and development of AF, and includes electrical remodeling, structural remodel

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8506732 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature