A novel immune-related ceRNA network that predicts prognosis and immunotherapy response in lung adenocarcinoma.

ABSTRACT:

Background

The tumor microenvironment plays an important role in the progression and malignancy of lung adenocarcinoma and affects the immunotherapy response. There is increasing evidence that long non-coding RNAs (lncRNAs) as competing endogenous RNAs (ceRNAs) have significant functions in the development and treatment response of various kinds of cancer. This study aimed to explore the association between immune-related lncRNA-microRNA (miRNA)-messenger RNA (mRNA)-ceRNA networks, and the prognosis of and immunotherapy response in lung adenocarcinoma.

Methods

RNA-sequencing (RNA-seq) and miRNA-seq data from The Cancer Genome Atlas (TCGA) were used to evaluate the infiltration of immune cells in lung adenocarcinoma samples by undertaking a single-sample gene set enrichment a

SUBMITTER: Gong WJ 

PROVIDER: S-EPMC8506752 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature