Dysregulation of tumor microenvironment promotes malignant progression and predicts risk of metastasis in bladder cancer.

ABSTRACT:

Background

The tumor microenvironment (TME) is not only a key factor in the malignant progression of cancer but also plays an indispensable role in tumor immunotherapy. As an important regulatory factor in the TME, long non-coding RNAs (incRNA) are important for the development of bladder cancer. The purpose of this study was to explore the molecular mechanism of malignant progression of bladder cancer (BCa) from the perspective of immunology, establish a reliable signature, and evaluate its effect on prognosis, metastasis, and the effectiveness of immunotherapy.

Methods

The TME was assessed by single-sample gene set enrichment analysis (ssGSEA) in 373 patients with muscle invasive bladder cancer (MIBC) in The Cancer Genome Atlas (TCGA). Combining RNA sequence data from 49 B

SUBMITTER: Liu J 

PROVIDER: S-EPMC8506754 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature