Protective effect of ultrasound microbubble combined with gross saponins of tribulus terrestris on glaucomatous optic nerve damage.

ABSTRACT:

Background

To investigate the protective effect of ultrasound microbubble combined with gross saponins of tribulus terrestris (GSTT) (a Chinese herb) on glaucomatous optic nerve damage.

Methods

Rabbits were randomly divided into five groups. Normal (Group A), high intraocular pressure (IOP, Group B), GSTT (Group C), GSTT + ultrasound (Group D), and GSTT + ultrasound + microbubble destruction (Group E). The high intraocular pressure eye (model eye) was compared to the normal eye (control eye) at 1, 2, and 4 weeks after model establishment. Rabbits were sacrificed 4 weeks later to measure the retina thickness using Cirrus OCT, slit lamp photograph, and fundus photography. The retina and optic nerve of rabbits in each group were collected and the stretched retina were pr

SUBMITTER: Shen X 

PROVIDER: S-EPMC8506763 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature