CCR4 is a prognostic biomarker and correlated with immune infiltrates in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Increased evidence has indicated that the tumour microenvironment plays an essential in the development, treatment and prognosis of head and neck squamous cell carcinoma (HNSC). Recent studies have indicated CC chemokine receptor 4 (CCR4) plays an essential role in tumor invasion and other adverse biological behavior. This study used data from the Cancer Genome Atlas (TCGA) database to explore the role of CCR4 in HNSC and its clinical significance.

Methods

The gene expression and clinical data of HNSC patients in the TCGA database were extracted. Gene Expression Profiling Interactive Analysis (GEPIA) was used to analyze the expression of CCR4 in tumor and non-tumor tissue. Kaplan-Meier survival analysis was used to analyze the relationship between

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8506764 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature