Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care.

ABSTRACT:

Objective

Familial hypercholesterolaemia (FH) is a common inherited disorder causing premature coronary heart disease (CHD) and death. We have developed the novel Familial Hypercholesterolaemia Case Ascertainment Tool (FAMCAT 1) case-finding algorithm for application in primary care, to improve detection of FH. The performance of this algorithm was further improved by including personal history of premature CHD (FAMCAT 2 algorithm). This study has evaluated their performance, at 95% specificity, to detect genetically confirmed FH in the general population. We also compared these algorithms to established clinical case-finding criteria.

Methods

Prospective validation study, in 14 general practices, recruiting participants from the general adult population with cholesterol doc

SUBMITTER: Qureshi N 

PROVIDER: S-EPMC8506870 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature