Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids.

ABSTRACT:

Background

Human cerebral organoids (hCO) are attractive systems due to their ability to model important brain regions and transcriptomics of early in vivo brain development. To date, they have been used to understand the effects of genetics and soluble factors on neurodevelopment. Interestingly, one of the main advantages of hCOs are that they provide three dimensionality that better mimics the in vivo environment; yet, despite this central feature it remains unclear how spatial and mechanical properties regulate hCO and neurodevelopment. While biophysical factors such as shape and mechanical forces are known to play crucial roles in stem cell differentiation, embryogenesis and neurodevelopment, much of this work investigated two dimensional systems or relied on correlative observ

SUBMITTER: Sen D 

PROVIDER: S-EPMC8507123 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature