Intraoperative radiation therapy induces immune response activity after pancreatic surgery.

ABSTRACT:

Background

Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation therapy (IORT), which delivers targeted radiation to a tumour bed, is known to reduce local recurrence by directly killing tumour cells and modifying the tumour microenvironment.

Methods

Among 30 patients diagnosed with pancreatic cancer, 17 patients received IORT immediately after surgical resection. We investigated changes in the immune response induced by IORT by analysing the peritoneal fluid (PF) and blood of patients with and without IORT treatment after pancreatic cancer surgery. Further, we treated three pancreatic cell lines with PF to observe prolifer

SUBMITTER: Lee YS 

PROVIDER: S-EPMC8507125 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature