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Intraoperative radiation therapy induces immune response activity after pancreatic surgery.

ABSTRACT:

Background

Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation therapy (IORT), which delivers targeted radiation to a tumour bed, is known to reduce local recurrence by directly killing tumour cells and modifying the tumour microenvironment.

Methods

Among 30 patients diagnosed with pancreatic cancer, 17 patients received IORT immediately after surgical resection. We investigated changes in the immune response induced by IORT by analysing the peritoneal fluid (PF) and blood of patients with and without IORT treatment after pancreatic cancer surgery. Further, we treated three pancreatic cell lines with PF to observe proliferation and activity changes.

Results

Levels of cytokines involved in the PI3K/SMAD pathway were increased in the PF of IORT-treated patients. Moreover, IORT-treated PF inhibited the growth, migration, and invasiveness of pancreatic cancer cells. Changes in lymphocyte populations in the blood of IORT-treated patients indicated an increased immune response.

Conclusions

Based on the characterisation and quantification of immune cells in the blood and cytokine levels in the PF, we conclude that IORT induced an anti-tumour effect by activating the immune response, which may prevent pancreatic cancer recurrence.

Clinical trial registration

NCT03273374 .

SUBMITTER: Lee YS

PROVIDER: S-EPMC8507125 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Intraoperative radiation therapy induces immune response activity after pancreatic surgery.

Lee Yun Sun YS Kim Hyung Sun HS Cho Yeona Y Lee Ik Jae IJ Kim Hyo Jung HJ Lee Da Eun DE Kang Hyeon Woong HW Park Joon Seong JS

BMC cancer 20211012 1

<h4>Background</h4>Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation therapy (IORT), which delivers targeted radiation to a tumour bed, is known to reduce local recurrence by directly killing tumour cells and modifying the tumour microenvironment.<h4>Methods</h4>Among 30 patients diagnosed with pancreatic cancer, 17 patients received IORT im ...[more]

PMID: 34641806

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Dataset Information

Intraoperative radiation therapy induces immune response activity after pancreatic surgery.

Background

Methods

Results

Conclusions

Clinical trial registration

Publications

Intraoperative radiation therapy induces immune response activity after pancreatic surgery.

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