A Real-World, Multicenter, Observational Retrospective Study of Durvalumab After Concomitant or Sequential Chemoradiation for Unresectable Stage III Non-Small Cell Lung Cancer.

ABSTRACT:

Introduction

For unresectable stage III non-small cell lung cancer (NSCLC), the standard therapy consists of chemoradiotherapy (CRT) followed by durvalumab maintenance for responding patients. The present study reports on the safety and outcome of durvalumab use after CRT in a real-world, multicenter, retrospective cohort.

Methods

Two hundred thirty-eight patients have been included. We collected data on systemic therapy, radiation therapy, the timing between CRT and durvalumab, number of durvalumab cycles, reasons for non-starting or discontinuation, incidence and grade of adverse events (AEs), and progression-free survival (PFS) and overall survival (OS).

Results

One hundred fifty-five patients out of 238 (65.1%) received at least one durvalumab dose: 91 (58.7%) aft

SUBMITTER: Bruni A 

PROVIDER: S-EPMC8507147 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature