Smoking, DNA Methylation, and Breast Cancer: A Mendelian Randomization Study.

ABSTRACT:

Background

Smoking was strongly associated with breast cancer in previous studies. Whether smoking promotes breast cancer through DNA methylation remains unknown.

Methods

Two-sample Mendelian randomization (MR) analyses were conducted to assess the causal effect of smoking-related DNA methylation on breast cancer risk. We used 436 smoking-related CpG sites extracted from 846 middle-aged women in the ARIES project as exposure data. We collected summary data of breast cancer from one of the largest meta-analyses, including 69,501 cases for ER+ breast cancer and 21,468 cases for ER- breast cancer. A total of 485 single-nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs) for smoking-related DNA methylation. We further performed an MR Steiger test to est

SUBMITTER: Tang H 

PROVIDER: S-EPMC8507148 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature