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New targets for NAFLD.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our understanding of its aetiology and pathophysiology. Despite the progress made, there are currently no effective treatments for NAFLD. In this review, we will provide an update on the known molecular pathways involved in the pathophysiology of NAFLD and on ongoing studies of new therapeutic targets.

SUBMITTER: Parlati L

PROVIDER: S-EPMC8507191 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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New targets for NAFLD.

Parlati Lucia L Régnier Marion M Guillou Hervé H Postic Catherine C

JHEP reports : innovation in hepatology 20210808 6

Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our understanding of its aetiology and pathophysiology. Despite the progress made, there are currently no effective treatments for NAFLD. In this review, we will provide an update on the known molecular pathways inv ...[more]

PMID: 34667947

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